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TargetTyrosine-protein kinase BTK
LigandBDBM263536
Substrate/Competitorn/a
Meas. Tech.TR-FRET (Time Resolved FRET) Assay
pH7.15±n/a
IC50 35.0±0 nM
Commentsextracted
Citation Lopez-Tapia, FJKong, NSo, SLou, YDominique, R Inhibitors of bruton's tyrosine kinase US Patent US9556150 Publication Date 1/31/2017
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase BTK
Name:Tyrosine-protein kinase BTK
Synonyms:ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK | Tyrosine-protein kinase BTK (BTK)
Type:Enzyme
Mol. Mass.:76289.95
Organism:Homo sapiens (human)
Description:Q06187
Residue:659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM263536
NameBDBM263536
Synonyms:US9556150, i-24 | {5-amino-1-[4-(2,3-difluoro- phenoxy)-2,6-dimethyl-phenyl]- 1h-pyrazol-4-yl}-[5- (morpholine-4-carbonyl)-1h- indol-2-yl]-methanone
TypeSmall organic molecule
Emp. Form.C31H27F2N5O4
Mol. Mass.571.574
SMILESCc1cc(Oc2cccc(F)c2F)cc(C)c1-n1ncc(C(=O)c2cc3cc(ccc3[nH]2)C(=O)N2CCOCC2)c1N |(2.59,3.66,;3.68,2.57,;5.17,2.97,;6.26,1.88,;7.75,2.28,;8.84,1.19,;8.44,-.3,;9.53,-1.39,;11.01,-.99,;11.41,.5,;12.9,.9,;10.32,1.59,;10.72,3.07,;5.86,.39,;4.37,-.01,;3.98,-1.5,;3.28,1.08,;1.8,.68,;.55,1.59,;-.69,.68,;-.22,-.78,;-.99,-2.12,;-.22,-3.45,;-2.53,-2.12,;-3.43,-.87,;-4.9,-1.35,;-6.23,-.58,;-7.57,-1.35,;-7.57,-2.89,;-6.23,-3.66,;-4.9,-2.89,;-3.43,-3.36,;-8.9,-.58,;-8.9,.96,;-10.23,-1.35,;-11.57,-.58,;-12.9,-1.35,;-12.9,-2.89,;-11.57,-3.66,;-10.23,-2.89,;1.32,-.78,;2.09,-2.12,)|
Structure
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