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TargetAurora kinase B
LigandBDBM27084
Substrate/CompetitorBiotinylated Cross-tide Substrate
Meas. Tech.Aurora Kinase Assay
pH8.5±n/a
Temperature295.15±n/a K
IC50 5.2±n/a nM
Citation Howard, SBerdini, VBoulstridge, JACarr, MGCross, DMCurry, JDevine, LAEarly, TRFazal, LGill, ALHeathcote, MMaman, SMatthews, JEMcMenamin, RLNavarro, EFO'Brien, MAO'Reilly, MRees, DCReule, MTisi, DWilliams, GVinković, MWyatt, PG Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity. J Med Chem52:379-88 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Aurora kinase B
Name:Aurora kinase B
Synonyms:AIM-1 | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | Serine/threonine-protein kinase aurora B
Type:Protein
Mol. Mass.:39327.72
Organism:Homo sapiens (Human)
Description:Q96GD4
Residue:344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM27084
NameBDBM27084
Synonyms:1-cyclohexyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-2-yl]-1H-pyrazol-4-yl}urea | pyrazole-benzimidazole urea analogue, 13
TypeSmall organic molecule
Emp. Form.C22H29N7O2
Mol. Mass.423.5114
SMILESO=C(NC1CCCCC1)Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
Biotinylated Cross-tide Substrate
Name:Biotinylated Cross-tide Substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:2578.93
Organism:n/a
Description:n/a
Residue:24
Sequence:
biotin-CGPKGPGRRGRRRTSSFAEG