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Target
Histone deacetylase 8
Ligand
BDBM27181
Substrate
Fluor de Lys-HDAC8 Fluorogenic Deacetylase Substrate
Meas. Tech.
HDAC Activity Assay
pH
8±n/a
Temperature
310.15±n/a K
IC50
7130±n/a nM
Citation
 Oyelere, AK; Chen, PC; Guerrant, W; Mwakwari, SC; Hood, R; Zhang, Y; Fan, Y Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem 52:456-68 (2009) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM27181
Synonyms:
triazole-linked azithromycin-based compound, 16e
Type:
n/a
Emp. Form.:
C54H92N6O14
Mol. Mass.:
1049.3401
SMILES:
CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)Cc2ccc(cc2)-c2cn(CCCCCCCC(=O)NO)nn2)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Fluor de Lys-HDAC8 Fluorogenic Deacetylase Substrate
Synonyms:
n/a
Type:
fluorogenic, diacetylated peptide
Mol. Mass.:
1716.47
Organism:
n/a
Description:
Residues 379-382 of p53.
Residue:
16
Sequence:
ARGHISLYSACLYSAC