Reaction Details Report a problem with these data
Target
Neutrophil collagenase
Ligand
BDBM50442356
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
13000±2000 nM
Citation
 Chang, M; Mobashery, S Selective matrix metalloproteinase inhibitors US Patent  US9951035 Publication Date 4/24/2018 
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM50442356
Synonyms:
CHEMBL2442885 | US10357546, ND-380 | US9951035, ND-380
Type:
Small organic molecule
Emp. Form.:
C17H17NO5S2
Mol. Mass.:
379.451
SMILES:
COC(=O)Nc1ccc(Oc2ccc(cc2)S(=O)(=O)CC2CS2)cc1
Structure:
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