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Target
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
Ligand
BDBM27412
Substrate
MCM2
Meas. Tech.
In Vitro Kinase Assay
IC50
4±n/a nM
Citation
 Vanotti, E; Amici, R; Bargiotti, A; Berthelsen, J; Bosotti, R; Ciavolella, A; Cirla, A; Cristiani, C; D'Alessio, R; Forte, B; Isacchi, A; Martina, K; Menichincheri, M; Molinari, A; Montagnoli, A; Orsini, P; Pillan, A; Roletto, F; Scolaro, A; Tibolla, M; Valsasina, B; Varasi, M; Volpi, D; Santocanale, C Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships. J Med Chem 51:487-501 (2008) [PubMed]  Article 
Target
Name:
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
Synonyms:
Cdc7 Kinase | Cdc7/DBF4
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cell division cycle 7-related protein kinase [58-574]
Synonyms:
CDC7 | CDC7L1 | CDC7_HUMAN | Cdc7 Kinase | Cell division cycle 7-related protein kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
57470.88
Organism:
Homo sapiens (Human)
Description:
O00311[58-574]
Residue:
517
Sequence:
FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
  
Component 2
Name:
Protein DBF4 homolog A
Synonyms:
ASK | Activator of S phase kinase | Chiffon homolog A | DBF4 | DBF4-type zinc finger-containing protein 1 | DBF4A | DBF4A_HUMAN | Protein DBF4 homolog A | ZDBF1
Type:
Regulatory subunit
Mol. Mass.:
76869.65
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
674
Sequence:
MNSGAMRIHSKGHFQGGIQVKNEKNRPSLKSLKTDNRPEKSKCKPLWGKVFYLDLPSVTISEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRISPVPSPESAYTAETTSPHPSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIPSNSILSNALSWGVKILHIDDIRYYIEQKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMPFINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLSPVSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVDHYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIFTHDSGLITINSSQEHLTVQAKAPFHTPPEEPNECDFKNMDSLPSGKIHRKVKIILGRNRKENLEPNAEFDKRTEFITQEENRICSSPVQSLLDLFQTSEEKSEFLGFTSYTEKSGICNVLDIWEEENSDNLLTAFFSSPSTSTFTGF
  
Inhibitor
Name:
BDBM27412
Synonyms:
2-(2-aminopyrimidin-4-yl)-1-(cyclopropylmethyl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one | pyrrolopyridinone scaffold, 34
Type:
Small organic molecule
Emp. Form.:
C15H17N5O
Mol. Mass.:
283.3284
SMILES:
Nc1nccc(n1)-c1cc2c(CCNC2=O)n1CC1CC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
MCM2
Synonyms:
BM28 | CCNL1 | CDCL1 | DNA replication licensing factor MCM2 | KIAA0030 | MCM2 | MCM2_HUMAN | Minichromosome maintenance protein 2 homolog | Nuclear protein BM28
Type:
Other Protein Type
Mol. Mass.:
32619.37
Organism:
Homo sapiens (Human)
Description:
P49736[10-294]
Residue:
285
Sequence:
MASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQRDREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEEL