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Target
Tyrosine-protein kinase BTK
Ligand
BDBM390091
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
505±n/a nM
Citation
 Liu, D; Zhang, M; Hu, Q Aminopyridazinone compounds as protein kinase inhibitors US Patent  US9951077 Publication Date 4/24/2018 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM390091
Synonyms:
US9951077, 103
Type:
Small organic molecule
Emp. Form.:
C28H26FN5O3
Mol. Mass.:
499.5361
SMILES:
NC(=O)C#CCC1CCC(CC1)n1cc(-c2ccc(Oc3ccccc3F)cc2)c2c(N)n[nH]c(=O)c12 |(1.23,10.99,;-.28,11.31,;-.75,12.77,;-1.31,10.16,;-2.34,9.02,;-3.37,7.87,;-2.89,6.41,;-3.92,5.27,;-3.45,3.8,;-1.94,3.48,;-.91,4.63,;-1.39,6.09,;-1.46,2.02,;-2.37,.77,;-1.46,-.48,;-1.94,-1.94,;-.91,-3.09,;-1.39,-4.55,;-2.89,-4.87,;-3.37,-6.33,;-4.87,-6.65,;-5.91,-5.51,;-7.41,-5.83,;-7.89,-7.29,;-6.86,-8.44,;-5.35,-8.12,;-4.32,-9.26,;-3.92,-3.73,;-3.45,-2.26,;;1.33,-.77,;1.33,-2.31,;2.67,,;2.67,1.54,;1.33,2.31,;1.33,3.85,;,1.54,)|
Structure:
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