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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM390181
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
21.0±n/a nM
Citation
 Bothe, U; Siebeneicher, H; Schmidt, N; Rotgeri, A; Bömer, U; Ring, S; Irlbacher, H; Günther, J; Steuber, H; Lange, M; Schäfer, M Indazolecarboxamides, processes for their preparation, pharmaceutical preparations comprising them and their use for producing medicaments US Patent  US9951086 Publication Date 4/24/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM390181
Synonyms:
US9951086, Example 70
Type:
Small organic molecule
Emp. Form.:
C26H30F3N5O4
Mol. Mass.:
533.5427
SMILES:
CCOc1cc2nn(CC(=O)N3CCC(CC3)C(C)(C)O)cc2cc1NC(=O)c1cccc(n1)C(F)(F)F
Structure:
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