Target

Ligand

Substrate

Meas. Tech.

PARP Enzyme Inhibition Assay

Temperature

298.15±n/a K

Citation

 Ishida, J; Yamamoto, H; Kido, Y; Kamijo, K; Murano, K; Miyake, H; Ohkubo, M; Kinoshita, T; Warizaya, M; Iwashita, A; Mihara, K; Matsuoka, N; Hattori, K Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling. Bioorg Med Chem 14:1378-90 (2006) [PubMed]  Article Copy BDB DOI

More Info.:

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Name:

Poly [ADP-ribose] polymerase 2

Synonyms:

2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 2 | ADPRT-2 | ARTD2 | Adprt2 | Adprtl2 | Aspartl2 | DNA ADP-ribosyltransferase PARP2 | NAD(+) ADP-ribosyltransferase 2 | PARP-2 | PARP2_MOUSE | Parp2 | Poly (ADP-ribose) Polymerase-2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (Parp2) | Poly [ADP-ribose] polymerase-2 | Poly[ADP-ribose] synthase 2 | Poly[ADP-ribose] synthetase 2 | Protein poly-ADP-ribosyltransferase PARP2 | mPARP-2 | pADPRT-2 | poly-ADP-ribose polymerase 2 (PARP2)

Type:

n/a

Mol. Mass.:

63409.97

Organism:

Mus musculus (Mouse)

Description:

Alexis Biochemicals, Cat. no. ALX-201-064-C020

Residue:

559

Sequence:

MAPRRQRSGSGRRVLNEAKKVDNGNKATEDDSPPGKKMRTCQRKGPMAGGKDADRTKDNRDSVKTLLLKGKAPVDPECAAKLGKAHVYCEGDDVYDVMLNQTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKTGQHSLVTCSGDLNKAKEIFQKKFLDKTKNNWEDRENFEKVPGKYDMLQMDYAASTQDESKTKEEETLKPESQLDLRVQELLKLICNVQTMEEMMIEMKYDTKRAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALVEACNEFYTRIPHDFGLSIPPVIRTEKELSDKVKLLEALGDIEIALKLVKSERQGLEHPLDQHYRNLHCALRPLDHESNEFKVISQYLQSTHAPTHKDYTMTLLDVFEVEKEGEKEAFREDLPNRMLLWHGSRLSNWVGILSHGLRVAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAQGLLRGKHSTKGMGKMAPSPAHFITLNGSTVPLGPASDTGILNPEGYTLNYNEFIVYSPNQVRMRYLLKIQFNFLQLW

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Blast E-value cutoff:

Name:

BDBM27713

Synonyms:

1-[4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl]-1,2,3,4-tetrahydroquinazoline-2,4-dione | quinazolidinone analogue, 2a

Type:

Small organic molecule

Emp. Form.:

C23H25N3O2

Mol. Mass.:

375.4635

SMILES:

O=c1[nH]c(=O)c2ccccc2n1CCCCN1CCC(=CC1)c1ccccc1 |c:21|

Structure:

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Similarity to this molecule at least:

Name:

BDBM27683

Synonyms:

[adenylate-32P]-NAD

Type:

radiolabeled substrate

Emp. Form.:

n/a

Mol. Mass.:

n/a

SMILES:

n/a

Structure: