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Target
Mitogen-activated protein kinase 8
Ligand
BDBM27808
Substrate
Biotin-GST-c-JUN
Meas. Tech.
JNK1 Inhibition Assay
IC50
1585±n/a nM
Citation
 Chamberlain, SD; Redman, AM; Wilson, JW; Deanda, F; Shotwell, JB; Gerding, R; Lei, H; Yang, B; Stevens, KL; Hassell, AM; Shewchuk, LM; Leesnitzer, MA; Smith, JL; Sabbatini, P; Atkins, C; Groy, A; Rowand, JL; Kumar, R; Mook, RA; Moorthy, G; Patnaik, S Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity. Bioorg Med Chem Lett 19:360-4 (2009) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 8
Synonyms:
JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48297.57
Organism:
Homo sapiens (Human)
Description:
JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
427
Sequence:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAAGPLGCCR
  
Inhibitor
Name:
BDBM27808
Synonyms:
2-fluoro-6-({2-[(5-methoxy-1-{2-[4-(propan-2-yl)piperazin-1-yl]acetyl}-2,3-dihydro-1H-indol-6-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)benzamide | pyrrolo[2,3-d]pyrimidine deriv., 31
Type:
Small organic molecule
Emp. Form.:
C31H36FN9O3
Mol. Mass.:
601.6744
SMILES:
COc1cc2CCN(C(=O)CN3CCN(CC3)C(C)C)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Biotin-GST-c-JUN
Synonyms:
JUN_RAT | Jun | Rjg-9
Type:
Other Protein Type
Mol. Mass.:
8641.27
Organism:
Rattus norvegicus (rat)
Description:
GST-c-Jun (1-79) fusion protein was biotinylated.
Residue:
79
Sequence:
MTAKMETTFYDDALNASFLQSESGAYGYSNPKILKQSMTLNLADPVGNLKPHLRAKNSDLLTSPDVGLLKLASPELERL