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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM391505
Substrate
n/a
Meas. Tech.
BRD4 AlphaScreen Assay
IC50
550±n/a nM
Citation
 Combs, AP; Maduskuie, Jr., TP; Falahatpisheh, N 1H-pyrrolo[2,3,c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins US Patent  US9957268 Publication Date 5/1/2018 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM391505
Synonyms:
US10472358, Example 5 | US10781209, Example 5 | US11059821, Example 5 | US11702416, Example 5 | US9957268, Example 5
Type:
Small organic molecule
Emp. Form.:
C21H16N4O3
Mol. Mass.:
372.3767
SMILES:
Cn1cc(-c2cccc3NC(=O)C(Oc23)c2ccccn2)c2cc[nH]c2c1=O
Structure:
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