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Target
Complex of Baculoviral IAP repeat-containing protein 7 [63-159,S150G] and E3 ubiquitin-protein ligase XIAP [336-348]
Ligand
BDBM27932
Substrate
BDBM17342
Meas. Tech.
Fluorescence Polarization Affinity Measurements
pH
7.2±n/a
Temperature
295.15±n/a K
Ki
1800±n/a nM
Citation
 Cohen, F; Alicke, B; Elliott, LO; Flygare, JA; Goncharov, T; Keteltas, SF; Franklin, MC; Frankovitz, S; Stephan, JP; Tsui, V; Vucic, D; Wong, H; Fairbrother, WJ Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold. J Med Chem 52:1723-30 (2009) [PubMed]  Article 
Target
Name:
Complex of Baculoviral IAP repeat-containing protein 7 [63-159,S150G] and E3 ubiquitin-protein ligase XIAP [336-348]
Synonyms:
Chimeric protein of melanoma inhibitor of apoptosis protein and XIAP-BIR3 | ML-IAP-BIR | MLXBIR3SG
Type:
Chimeric Protein
Mol. Mass.:
14953.37
Organism:
Homo sapiens (Human)
Description:
Q96CA5[63-159,S150G],P98170[336-348]
Residue:
133
Sequence:
MGSSHHHHHHSSGEVPRGSHMLETEEEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFPGCQFLLRSKGQEYINNIHLTHSL
  
Inhibitor
Name:
BDBM27932
Synonyms:
Azabicyclooctane scaffold, 14o | N-[(3aR,6S,6aS)-1-[(2S)-3,3-dimethyl-2-[(2S)-2-(methylamino)propanamido]butanoyl]-octahydrocyclopenta[b]pyrrol-6-yl]-2,1,3-benzoxadiazole-5-carboxamide
Type:
Small organic molecule
Emp. Form.:
C24H34N6O4
Mol. Mass.:
470.5646
SMILES:
[H][C@]12CC[C@H](NC(=O)c3ccc4nonc4c3)[C@@]1([H])N(CC2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM17342
Synonyms:
5-carboxyflourescein(5-FAM)-conjugated AVPFFAKK | AVP-diPhe-FAM
Type:
Fluorescent dye-conjugated peptide
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: