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Target
Beta-2 adrenergic receptor
Ligand
BDBM27955
Substrate
BDBM25747
Meas. Tech.
Beta-2 Adrenergic Receptor Binding Assay and Agonist Functionality Assay
pH
7.4±n/a
Temperature
295.15±n/a K
Ki
320±n/a nM
IC50
620±n/a nM
EC50
8.7±n/a nM
Citation
 Kern, C; Meyer, T; Droux, S; Schollmeyer, D; Miculka, C Synthesis and pharmacological characterization of beta2-adrenergic agonist enantiomers: zilpaterol. J Med Chem 52:1773-7 (2009) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM27955
Synonyms:
(-)-Zilpaterol | (9R,10R)-9-hydroxy-10-(propan-2-ylamino)-1,3-diazatricyclo[6.4.1.0^{4,13}]trideca-4(13),5,7-trien-2-one
Type:
Small organic molecule
Emp. Form.:
C14H19N3O2
Mol. Mass.:
261.3196
SMILES:
CC(C)N[C@@H]1CCn2c3c(cccc3[nH]c2=O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM25747
Synonyms:
4-[3-(tert-butylamino)-2-hydroxypropoxy]-2,3-dihydro-1H-1,3-benzodiazol-2-one hydrochloride | CGP 12177 | CGP-12177 | CGP12177 | [3H]CGP 12177
Type:
radiolabeled ligand
Emp. Form.:
C14H21N3O3
Mol. Mass.:
279.3348
SMILES:
CC(C)(C)NCC(O)COc1cccc2[nH]c(=O)[nH]c12
Structure:
Search PDB for entries with ligand similarity: