Reaction Details Report a problem with these data
Target
Receptor activity-modifying protein 1
Ligand
BDBM391721
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
0.100±n/a nM
Citation
 Christopher, JA; Congreve, MS; Bucknell, SJ; Deflorian, F; Pickworth, M; Mason, JS CGRP receptor antagonists US Patent  US10300056 Publication Date 5/28/2019 
Target
Name:
Receptor activity-modifying protein 1
Synonyms:
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 | RAMP1 | RAMP1_HUMAN
Type:
PROTEIN
Mol. Mass.:
16992.80
Organism:
Homo sapiens (Human)
Description:
EBI_100673
Residue:
148
Sequence:
MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKRTEGIV
  
Inhibitor
Name:
BDBM391721
Synonyms:
N-[(2R)-3-(7-methyl-1H- | US10300056, Example 6 | US10888561, Example 6
Type:
Small organic molecule
Emp. Form.:
C48H60N10O5
Mol. Mass.:
857.054
SMILES:
CCCCC(=O)N1CCC(C[C@H](NC(=O)[C@@H](Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(CC2)c2cc3ccccc3[nH]c2=O)C(=O)N2CCN(CC2)c2ccncc2)CC1 |r|
Structure:
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