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Target
E3 ubiquitin-protein ligase XIAP [1-168]/[124-242]
Ligand
BDBM391827
Substrate
n/a
Meas. Tech.
Biological Assays
Ki
>50000±n/a nM
Citation
 Pache, L; Chanda, SK; Vamos, MD; Cosford, ND; Teriete, P; Marlett, J; Diaz, A; Young, JA Use of inhibitor of apoptosis protein (IAP) antagonists in HIV therapy US Patent  US10300074 Publication Date 5/28/2019 
Target
Name:
E3 ubiquitin-protein ligase XIAP [1-168]/[124-242]
Synonyms:
XIAP BIR1/2
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
E3 ubiquitin-protein ligase XIAP [1-168]
Synonyms:
API3 | BIRC4 | IAP3 | XIAP | XIAP BIR1 | XIAP_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18844.56
Organism:
Homo sapiens (Human)
Description:
P98170[1-168]
Residue:
168
Sequence:
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLK
  
Component 2
Name:
E3 ubiquitin-protein ligase XIAP [124-242]
Synonyms:
API3 | BIRC4 | IAP3 | XIAP | XIAP BIR2 | XIAP_HUMAN
Type:
n/a
Mol. Mass.:
13841.77
Organism:
Homo sapiens (Human)
Description:
P98170[124-242]
Residue:
119
Sequence:
RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESD
  
Inhibitor
Name:
BDBM391827
Synonyms:
US10300074, Compd 22 | US10300074, Compd 23
Type:
Small organic molecule
Emp. Form.:
C21H26N4O4
Mol. Mass.:
398.4555
SMILES:
CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CCC(N2C1=O)C(=O)n1ccc2ccccc12 |r|
Structure:
Search PDB for entries with ligand similarity: