Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM392668
Substrate
n/a
Meas. Tech.
Test for Evaluating Human MC Receptor Activation, Using Cells Expressing Human MC4, MC1, or MC3 Receptor
EC50
2400±n/a nM
Citation
 Sugane, T; Makino, T; Yamashita, D; Yonetoku, Y; Tanabe, D; Mihara, H; Asai, N; Osoda, K; Shimizu, T; Moritomo, H; Sugasawa, K; Maeno, K; Hosogai, N Piperazine derivative US Patent  US10301286 Publication Date 5/28/2019 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM392668
Synonyms:
US10301286, Example 17
Type:
Small organic molecule
Emp. Form.:
C34H39F2N3O3
Mol. Mass.:
575.6886
SMILES:
CC(C)(C)N1C[C@H]([C@@H](C1)c1ccc(F)cc1F)C(=O)N1CCN(CC11CC1)[C@@H](Cc1ccc2ccccc2c1)C(O)=O |r|
Structure:
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