Reaction Details Report a problem with these data
Target
Receptor-interacting serine/threonine-protein kinase 3
Ligand
BDBM392813
Substrate
n/a
Meas. Tech.
RIPK3 HTRF Kinase Assay
IC50
7550±n/a nM
Citation
 Hart, AC; Pitts, WJ; Mastalerz, H; Guo, J; Brown, GD Substituted dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones as RIPK3 inhibitors US Patent  US10301306 Publication Date 5/28/2019 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 3
Synonyms:
RIP-3 | RIP-like protein kinase 3 | RIP3 | RIPK3 | RIPK3_HUMAN | Receptor-interacting protein 3
Type:
PROTEIN
Mol. Mass.:
56886.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_881455
Residue:
518
Sequence:
MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
  
Inhibitor
Name:
BDBM392813
Synonyms:
2-((2-(2-Chloropyridin-4-yl)-4-oxo-3-(pyridin-3-yl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)methyl)-5-fluorobenzonitrile | US10301306, Example 11
Type:
Small organic molecule
Emp. Form.:
C25H17ClFN5O
Mol. Mass.:
457.887
SMILES:
Fc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccnc(Cl)c2)-c2cccnc2)c(c1)C#N
Structure:
Search PDB for entries with ligand similarity: