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Target
Receptor-interacting serine/threonine-protein kinase 3
Ligand
BDBM392934
Substrate
n/a
Meas. Tech.
RIPK3 HTRF Kinase Assay
IC50
7550±n/a nM
Citation
 Hart, AC; Pitts, WJ; Mastalerz, H; Guo, J; Brown, GD Substituted dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones as RIPK3 inhibitors US Patent  US10301306 Publication Date 5/28/2019 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 3
Synonyms:
RIP-3 | RIP-like protein kinase 3 | RIP3 | RIPK3 | RIPK3_HUMAN | Receptor-interacting protein 3
Type:
PROTEIN
Mol. Mass.:
56886.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_881455
Residue:
518
Sequence:
MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
  
Inhibitor
Name:
BDBM392934
Synonyms:
US10301306, Example 132
Type:
Small organic molecule
Emp. Form.:
C29H20FN5O
Mol. Mass.:
473.5004
SMILES:
Fc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2cncc3ccccc23)c(c1)C#N |(4.3,-7.14,;3.21,-6.05,;3.61,-4.57,;2.52,-3.48,;1.03,-3.88,;-.06,-2.79,;.34,-1.3,;1.81,-.82,;3.14,-1.59,;4.47,-.82,;4.47,.72,;3.14,1.49,;3.14,3.03,;1.81,.72,;.34,1.19,;-.56,-.05,;-2.1,-.05,;-2.87,1.28,;-4.41,1.28,;-5.18,-.05,;-4.41,-1.39,;-2.87,-1.39,;-.06,2.68,;-1.54,3.08,;-1.94,4.57,;-.85,5.66,;.63,5.26,;1.72,6.35,;3.21,5.95,;3.61,4.46,;2.52,3.37,;1.03,3.77,;.58,-5.38,;1.72,-6.45,;-.91,-5.78,;-2.41,-6.1,)|
Structure:
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