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Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM393008
Substrate
n/a
Meas. Tech.
in vitro assay
IC50
2670±n/a nM
Citation
 Markowitz, S; Willson, JK; Posner, B; Ready, J; Zhang, Y; Tai, H; Antczak, M; Gerson, S; Bae, K; Yang, SY; Desai, A Compositions and methods of modulating 15-PGDH activity US Patent  US10301320 Publication Date 5/28/2019 
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM393008
Synonyms:
US10301320, ETSW ID SW202938
Type:
Small organic molecule
Emp. Form.:
C21H21N3O5S
Mol. Mass.:
427.474
SMILES:
COc1ccc(OC)c(c1)N(CC(=O)Nc1ccncc1)S(=O)(=O)c1ccccc1
Structure:
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