Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM330237
Substrate
n/a
Meas. Tech.
Human Factor D Assay
IC50
>10000±n/a nM
Citation
 Wiles, JA; Hashimoto, A; Gadhachanda, VR; Pais, G; Wang, Q; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Phadke, A Phosphonate compounds for treatment of complement mediated disorders US Patent  US10301336 Publication Date 5/28/2019 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM330237
Synonyms:
US10301336, Comp No. 13 | US9663543, Compound 13 | methyl 1-(2-((2S,4R)-2-(3- chloro-2- fluorobenzylcarbamoyl)-4- fluoropyrrolidin-1-yl)-2- oxoethyl)-6- (diethoxyphosphoryl)-1H- indole-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C28H31ClF2N3O7P
Mol. Mass.:
625.985
SMILES:
CCOP(=O)(OCC)c1ccc2c(cn(CC(=O)N3C[C@H](F)C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1)C(=O)OC |r|
Structure:
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