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Target
Eyes absent homolog 3
Ligand
BDBM50158457
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
81100±n/a nM
Citation
 Hegde, R Use of small molecule inhibitors targeting EYA tyrosine phosphatase US Patent  US9962362 Publication Date 5/8/2018 
Target
Name:
Eyes absent homolog 3
Synonyms:
EYA3 | EYA3_HUMAN | Eyes absent homolog 3 (EYA3)
Type:
Protein
Mol. Mass.:
62648.48
Organism:
Homo sapiens (Human)
Description:
Q99504
Residue:
573
Sequence:
MEEEQDLPEQPVKKAKMQESGEQTISQVSNPDVSDQKPETSSLASNLPMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETAYPGQTQYQTLQQTQPYAVYPQATQTYGLPPFGALWPGMKPESGLIQTPSPSQHSVLTCTTGLTTSQPSPAHYSYPIQASSTNASLISTSSTIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDAESTTLAATTYQSEKPSVMAPAPAAQRLSSGDPSTSPSLSQTTPSKDTDDQSRKNMTSKNRGKRKADATSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
  
Inhibitor
Name:
BDBM50158457
Synonyms:
(4-hydroxyphenyl)(2-methylbenzofuran-3-yl)methanone | CHEMBL374618 | US9725430, Compound 1k | US9962362, Compound 1k
Type:
Small organic molecule
Emp. Form.:
C16H12O3
Mol. Mass.:
252.2647
SMILES:
Cc1oc2ccccc2c1C(=O)c1ccc(O)cc1
Structure:
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