Reaction Details Report a problem with these data
Target
Cytochrome P450 26B1
Ligand
BDBM393281
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
3.10±n/a nM
Citation
 Diaz, P; Isoherranen, N; Buttrick, B; Guilloteau, N Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase US Patent  US9963439 Publication Date 5/8/2018 
Target
Name:
Cytochrome P450 26B1
Synonyms:
CP26B_HUMAN | CYP26A2 | CYP26A2 | CYP26B1 | Cytochrome P450 26A2 | Cytochrome P450 26B1 | Cytochrome P450 retinoic acid-inactivating 2 | Cytochrome P450RAI-2 | P450RAI2 | Retinoic acid-metabolizing cytochrome
Type:
PROTEIN
Mol. Mass.:
57525.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_115648
Residue:
512
Sequence:
MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV
  
Inhibitor
Name:
BDBM393281
Synonyms:
US9963439, R116010
Type:
Small organic molecule
Emp. Form.:
C21H23N5S
Mol. Mass.:
377.506
SMILES:
CC(C(c1ccc(Nc2nc3ccccc3s2)cc1)n1ccnc1)N(C)C
Structure:
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