Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM393465
Substrate
n/a
Meas. Tech.
Receptor Radioligand Assay
Ki
123±n/a nM
Citation
 Merce-Vidal, R; Díaz-Fernández, J; Almansa-Rosales, C Substituted pyrazino[1,2-a]indoles as sigma receptor activity modulators US Patent  US9963453 Publication Date 5/8/2018 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM393465
Synonyms:
1-(8-fluoro- 3,4- dihydro- pyrazino[1,2- a]indol- 2(1H)-yl)-2- (4-methyl-piperazin-1-yl)propan-1-one | US9963453, 26
Type:
Small organic molecule
Emp. Form.:
C19H25FN4O
Mol. Mass.:
344.4264
SMILES:
CC(N1CCN(C)CC1)C(=O)N1CCn2c(C1)cc1cc(F)ccc21
Structure:
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