Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM150369
Substrate
n/a
Meas. Tech.
Inhibition Assay of Human Cathepsin K
pH
3.5±n/a
Temperature
298.15±n/a K
IC50
2200±n/a nM
Comments
extracted
Citation
 Anderskewitz, R; Binder, F; Grauert, M; Grundl, M; Haebel, PW; Oost, T; Pautsch, A; Peters, S; Vintonyak, V Methods for treating pulmonary emphysema using substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C US Patent  US9713606 Publication Date 7/25/2017 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM150369
Synonyms:
US10238633, Example 43 | US8987249, 43 | US9713606, 43
Type:
Small organic molecule
Emp. Form.:
C23H30FN5O2
Mol. Mass.:
427.515
SMILES:
Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN2CCOCC2C1 |r|
Structure:
Search PDB for entries with ligand similarity: