Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM263595
Substrate
n/a
Meas. Tech.
WNT Pathway Reporter Gene Assay
IC50
<3.00±n/a nM
Citation
 An, S Compounds for treatment of cancer US Patent  US9713612 Publication Date 7/25/2017 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM263595
Synonyms:
US10087181, Compound 70 | US10285988, Compound 70 | US9713612, 70
Type:
Small organic molecule
Emp. Form.:
C26H22N6
Mol. Mass.:
418.4931
SMILES:
Cc1cc(ccn1)-c1ncc(CNc2nccc3cc(ccc23)-c2cnccn2)cc1C
Structure:
Search PDB for entries with ligand similarity: