Reaction Details Report a problem with these data
Target
P2X purinoceptor 4
Ligand
BDBM393617
Substrate
n/a
Meas. Tech.
Antagonist Activity Assay
IC50
440±0.0 nM
Citation
 Ushioda, M; Kobayashi, K; Saito, D; Sakuma, S; Imai, T; Inoue, K P2X4 receptor antagonist US Patent  US9969700 Publication Date 5/15/2018 
Target
Name:
P2X purinoceptor 4
Synonyms:
ATP receptor | P2RX4 | P2RX4_HUMAN | P2X4 | Purinergic receptor | Purinergic, P2X4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43374.70
Organism:
Homo sapiens (Human)
Description:
Purinergic, P2X4 0 HUMAN::Q99571
Residue:
388
Sequence:
MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKKYKYVEDYEQGLASELDQ
  
Inhibitor
Name:
BDBM393617
Synonyms:
US09969700, 197
Type:
Small organic molecule
Emp. Form.:
C26H20ClN3O3S
Mol. Mass.:
489.973
SMILES:
Clc1ccccc1CS(=O)(=O)Nc1ccc(cc1)C1=NCC(=O)Nc2c1ccc1ccccc21 |t:20|
Structure:
Search PDB for entries with ligand similarity: