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Target
Coagulation factor IX
Ligand
BDBM393720
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
IC50
<100±n/a nM
Citation
 Sakurada, I; Hirabayashi, T; Maeda, Y; Nagasue, H; Mizuno, T; Xu, J; Zhang, T; Smith, C; Parker, D Factor IXa inhibitors US Patent  US9969724 Publication Date 5/15/2018 
Target
Name:
Coagulation factor IX
Synonyms:
Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:
Enzyme
Mol. Mass.:
51768.83
Organism:
Homo sapiens (Human)
Description:
P00740
Residue:
461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
  
Inhibitor
Name:
BDBM393720
Synonyms:
(R)—N-(1-(3-Amino-5-methylisoxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl)-2,6-dichloro-4-(1-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)benzamide | US9969724, Example 49
Type:
Small organic molecule
Emp. Form.:
C21H20Cl2N8O3
Mol. Mass.:
503.341
SMILES:
Cc1cc2c(N)noc2c(n1)N1CC[C@H](C1)NC(=O)c1c(Cl)cc(cc1Cl)-n1cnn(C)c1=O |r|
Structure:
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