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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM29185
Substrate
BDBM29135
Meas. Tech.
MAO Enzyme Inhibition Assay
IC50
580±n/a nM
Citation
 Chimenti, F; Secci, D; Bolasco, A; Chimenti, P; Bizzarri, B; Granese, A; Carradori, S; Yáñez, M; Orallo, F; Ortuso, F; Alcaro, S Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem 52:1935-42 (2009) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM29185
Synonyms:
3-carboxamido coumarin, 35
Type:
Small organic molecule
Emp. Form.:
C15H6F4N2O3
Mol. Mass.:
338.2134
SMILES:
Fc1nc(F)c(F)c(NC(=O)c2cc3ccccc3oc2=O)c1F
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM29135
Synonyms:
CHEMBL11608 | cid_5610 | p-Tyramine | tyramine
Type:
Small organic molecule
Emp. Form.:
C8H11NO
Mol. Mass.:
137.179
SMILES:
NCCc1ccc(O)cc1
Structure:
Search PDB for entries with ligand similarity: