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Target
Substance-K receptor
Ligand
BDBM357797
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
>30000±n/a nM
Citation
 Hoveyda, H; Dutheuil, G; Fraser, G N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders US Patent  US9969738 Publication Date 5/15/2018 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM357797
Synonyms:
(3-(3-methyl-1,2,4- thiadiazol-5-yl)-5,6- dihydro-[1,2,4]triazolo[4,3- a]pyrazin-7(8H)-yl)(2,3,4- trifluorophenyl)methanone | US10214533, Compound 7 | US9969738, 7
Type:
Small organic molecule
Emp. Form.:
C15H11F3N6OS
Mol. Mass.:
380.348
SMILES:
Cc1nsc(n1)-c1nnc2CN(CCn12)C(=O)c1ccc(F)c(F)c1F
Structure:
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