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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM393909
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
11.0±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Torres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM393909
Synonyms:
US9969749, Example 1-3 | US9969749, Example 1-6 | cis or trans-N,N- dimethyl-N''-[6-(pyridin- 4-yl)quinazolin-4- yl]cyclohexane-1,4- diamine
Type:
Small organic molecule
Emp. Form.:
C21H25N5
Mol. Mass.:
347.4567
SMILES:
CN(C)C1CCC(CC1)Nc1ncnc2ccc(cc12)-c1ccncc1 |(4.62,-6,;3.08,-6,;2.31,-7.34,;2.31,-4.67,;.77,-4.67,;,-3.33,;.77,-2,;2.31,-2,;3.08,-3.33,;,-.67,;-1.54,-.67,;-2.31,-2,;-3.85,-2,;-4.62,-.67,;-3.85,.67,;-4.62,2,;-3.85,3.33,;-2.31,3.33,;-1.54,2,;-2.31,.67,;-1.54,4.67,;,4.67,;.77,6,;,7.34,;-1.54,7.34,;-2.31,6,)|
Structure:
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