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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM393946
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
43.0±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Torres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM393946
Synonyms:
3-(4-{[trans-4- (dimethylamino)cyclohexyl] amino}quinazolin-6- yl)pyridine-2- carbonitrile | US9969749, Example 1-39
Type:
Small organic molecule
Emp. Form.:
C22H24N6
Mol. Mass.:
372.4662
SMILES:
CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cccnc1C#N |r,wU:3.2,wD:6.9,(4.62,-6,;3.08,-6,;2.31,-7.34,;2.31,-4.67,;.77,-4.67,;,-3.33,;.77,-2,;2.31,-2,;3.08,-3.33,;,-.67,;-1.54,-.67,;-2.31,-2,;-3.85,-2,;-4.62,-.67,;-3.85,.67,;-4.62,2,;-3.85,3.33,;-2.31,3.33,;-1.54,2,;-2.31,.67,;-1.54,4.67,;-2.31,6,;-1.54,7.34,;,7.34,;.77,6,;,4.67,;.77,3.33,;1.54,2,)|
Structure:
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