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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM393955
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
9.00±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Torres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM393955
Synonyms:
N-[trans-4-(morpholin- 4-yl)cyclohexyl]-6- (pyridin-4- yl)quinazolin-4-amine | US9969749, Example 1-48
Type:
Small organic molecule
Emp. Form.:
C23H27N5O
Mol. Mass.:
389.4934
SMILES:
C1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1ccncc1 |r,wU:9.13,wD:6.6,(2.69,-8,;1.92,-6.67,;2.69,-5.33,;4.23,-5.33,;5.01,-6.67,;4.23,-8,;1.92,-4,;2.69,-2.67,;1.92,-1.33,;.38,-1.33,;-.39,-2.67,;.38,-4,;-.39,,;-1.93,,;-2.7,-1.33,;-4.24,-1.33,;-5.01,,;-4.24,1.33,;-5.01,2.67,;-4.24,4,;-2.7,4,;-1.93,2.67,;-2.7,1.33,;-1.93,5.33,;-.39,5.33,;.38,6.67,;-.39,8,;-1.93,8,;-2.7,6.67,)|
Structure:
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