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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM393986
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
1312±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Torres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM393986
Synonyms:
5-methyl-6-(1-methyl- 1H-pyrazol-4-yl)-N- (trans-4-morpholin-4- ylcyclohexyl)quinazolin- 4-amine | US9969749, Example 1-77
Type:
Small organic molecule
Emp. Form.:
C23H32N6O
Mol. Mass.:
408.5398
SMILES:
CN\C=C(/C=N)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1C |r,wU:15.14,wD:18.21,(1.42,7.72,;.09,6.95,;-.39,5.48,;-1.93,5.48,;-2.4,6.95,;-1.16,7.85,;-2.7,4.15,;-4.24,4.15,;-5.01,2.82,;-4.24,1.48,;-5.01,.15,;-4.24,-1.18,;-2.7,-1.18,;-1.93,.15,;-.39,.15,;.38,-1.18,;1.92,-1.18,;2.69,-2.52,;1.92,-3.85,;.38,-3.85,;-.39,-2.52,;2.69,-5.19,;1.92,-6.52,;2.69,-7.85,;4.23,-7.85,;5.01,-6.52,;4.23,-5.19,;-2.7,1.48,;-1.93,2.82,;-.39,2.82,)|
Structure:
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