Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM394002
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
24.0±n/a nM
Citation
 Altman, MDAndresen, BMBrubaker, JDChilders, MLDonofrio, AFischmann, TGibeau, CRKattar, SDLesburg, CALim, JMacLean, JKMansoor, UFNorthrup, ABSanders, JMTorres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM394002
Synonyms:
N-[5-(4-{[trans-4- (morpholin-4- yl)cyclohexyl]amino} quinazolin-6-yl)pyridin-3- yl]methanesulfonamide | US9969749, Example 1-92
Type:
Small organic molecule
Emp. Form.:
C24H30N6OS
Mol. Mass.:
450.6
SMILES:
CSNc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1 |r,wU:21.25,wD:18.18,(4.23,5.33,;2.69,5.33,;1.92,6.67,;.38,6.67,;-.39,8,;-1.93,8,;-2.7,6.67,;-1.93,5.33,;-.39,5.33,;-2.7,4,;-4.24,4,;-5.01,2.67,;-4.24,1.33,;-5.01,,;-4.24,-1.33,;-2.7,-1.33,;-1.93,,;-.39,,;.38,-1.33,;-.39,-2.67,;.38,-4,;1.92,-4,;2.69,-2.67,;1.92,-1.33,;2.69,-5.33,;1.92,-6.67,;2.69,-8,;4.23,-8,;5.01,-6.67,;4.23,-5.33,;-2.7,1.33,;-1.93,2.67,)|
Structure:
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