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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM394036
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
104±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Torres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM394036
Synonyms:
6-(3,5-dimethyl-1H- pyrazol-4-yl)-N-[trans- 4-(morpholin-4- yl)cyclohexyl]quinazolin- 4-amine | US9969749, Example 2-24
Type:
Small organic molecule
Emp. Form.:
C23H30N6O
Mol. Mass.:
406.5239
SMILES:
Cc1n[nH]c(C)c1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1 |r,wU:16.16,wD:19.23,(.38,4.15,;-.38,5.48,;.09,6.95,;-1.15,7.85,;-2.4,6.95,;-3.73,7.72,;-1.93,5.48,;-2.69,4.15,;-4.23,4.15,;-5,2.82,;-4.23,1.48,;-5,.15,;-4.23,-1.18,;-2.69,-1.18,;-1.93,.15,;-.38,.15,;.38,-1.18,;1.92,-1.18,;2.69,-2.52,;1.92,-3.85,;.38,-3.85,;-.39,-2.52,;2.69,-5.19,;1.92,-6.52,;2.69,-7.85,;4.23,-7.85,;5,-6.52,;4.23,-5.19,;-2.69,1.48,;-1.93,2.82,)|
Structure:
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