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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM394052
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
1.000±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Torres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM394052
Synonyms:
5-(4-{[trans-4-(3- methoxyazetidin-1- yl)cyclohexyl]amino} quinazolin-6-yl)pyridin-3-ol | US9969749, Example 5-2
Type:
Small organic molecule
Emp. Form.:
C23H27N5O2
Mol. Mass.:
405.4928
SMILES:
COC1CN(C1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(O)c1 |r,wU:6.6,wD:9.13,(5.55,-8.28,;4.01,-8.28,;3.24,-6.94,;1.75,-6.55,;2.15,-5.06,;3.64,-5.46,;1.38,-3.72,;-.16,-3.72,;-.93,-2.39,;-.16,-1.06,;1.38,-1.06,;2.15,-2.39,;-.93,.28,;-2.47,.28,;-3.24,-1.06,;-4.78,-1.06,;-5.55,.28,;-4.78,1.61,;-5.55,2.94,;-4.78,4.28,;-3.24,4.28,;-2.47,2.94,;-3.24,1.61,;-2.47,5.61,;-3.24,6.94,;-2.47,8.28,;-.93,8.28,;-.16,6.94,;1.38,6.94,;-.93,5.61,)|
Structure:
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