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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM394058
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
3.00±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Torres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM394058
Synonyms:
N-[trans-4-(4,4- difluoropiperidin-1- yl)cyclohexyl]-6-[5- (methylamino)pyridin-3- yl]quinazolin-4-amine | US9969749, Example 5-8
Type:
Small organic molecule
Emp. Form.:
C25H30F2N6
Mol. Mass.:
452.5427
SMILES:
CNc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC(F)(F)CC3)c2c1 |r,wU:20.24,wD:17.17,(2.31,8.67,;1.54,7.34,;,7.34,;-.77,8.67,;-2.31,8.67,;-3.08,7.34,;-2.31,6,;-.77,6,;-3.08,4.67,;-4.62,4.67,;-5.39,3.33,;-4.62,2,;-5.39,.67,;-4.62,-.67,;-3.08,-.67,;-2.31,.67,;-.77,.67,;,-.67,;-.77,-2,;,-3.33,;1.54,-3.33,;2.31,-2,;1.54,-.67,;2.31,-4.67,;1.54,-6,;2.31,-7.34,;3.85,-7.34,;5.39,-7.34,;4.62,-8.67,;4.62,-6,;3.85,-4.67,;-3.08,2,;-2.31,3.33,)|
Structure:
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