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Target
Beta-carbonic anhydrase 1
Ligand
BDBM10875
Substrate
BDBM10856
Meas. Tech.
CA Inhibition Assay
pH
8.3±n/a
Temperature
293.15±n/a K
Ki
7480±n/a nM
Citation
 Minakuchi, T; Nishimori, I; Vullo, D; Scozzafava, A; Supuran, CT Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate. J Med Chem 52:2226-32 (2009) [PubMed]  Article 
Target
Name:
Beta-carbonic anhydrase 1
Synonyms:
β-Carbonic anhydrase 1 (CA 1) | Carbonic Anhydrase (mtCA 1) | MTCA1_MYCTU | Uncharacterized protein Rv1284/MT1322 | canA | mtcA1
Type:
Enzyme
Mol. Mass.:
18186.06
Organism:
Mycobacterium tuberculosis
Description:
The recombinant GST-mtCA1 construct was cloned, expressed, and further purified from E. coli. The purified protein was used in inhibition assays.
Residue:
163
Sequence:
MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRMLGIKEGEAHVIRNAGCVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRAIQDETGIRPTWSPESYPDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP
  
Inhibitor
Name:
BDBM10875
Synonyms:
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide | CHEMBL360356 | Chlorzolamide, CHL | JMC522226 Compound 19 | JMC523116 Compound 19 | aromatic/heteroaromatic sulfonamide 20
Type:
Small organic molecule
Emp. Form.:
C8H6ClN3O2S2
Mol. Mass.:
275.735
SMILES:
NS(=O)(=O)c1nnc(s1)-c1ccccc1Cl
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM10856
Synonyms:
Carbon Dioxide | methanedione
Type:
Small organic molecule
Emp. Form.:
CO2
Mol. Mass.:
44.0095
SMILES:
O=C=O
Structure:
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