Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM394209
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
42.0±n/a nM
Citation
 Kuduk, SD; Skudlarek, JW 2-pyridyloxy-3-ester-4-ether orexin receptor antagonists US Patent  US9975876 Publication Date 5/22/2018 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM394209
Synonyms:
US9975876, 34 | methyl 2-methoxy-6-({(3R,6R)-6- methyl-1-[(2-pyrimidin-2- ylthiophen-3-yl)carbonyl]piperidin- 3-yl}oxy)benzoate
Type:
Small organic molecule
Emp. Form.:
C24H25N3O5S
Mol. Mass.:
467.537
SMILES:
COC(=O)c1c(OC)cccc1O[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccsc1-c1ncccn1
Structure:
Search PDB for entries with ligand similarity: