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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM29538
Substrate
BDBM21393
Meas. Tech.
Radioligand Binding Assay (Ki)
pH
7.4±n/a
Temperature
310.15±n/a K
Ki
375±n/a nM
Citation
 Badarau, E; Suzenet, F; Bojarski, AJ; Fînaru, AL; Guillaumet, G Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: synthesis and biological evaluation. Bioorg Med Chem Lett 19:1600-3 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM29538
Synonyms:
benzimidazolone scaffold, 8f
Type:
Small organic molecule
Emp. Form.:
C27H30N4O
Mol. Mass.:
426.5533
SMILES:
Cc1ccccc1N1CCN(CCn2c3ccccc3n(-c3ccccc3C)c2=O)CC1 |(1.69,4.1,;1.69,5.64,;3.03,6.41,;3.03,7.95,;1.69,8.72,;.36,7.95,;.36,6.41,;-.97,5.64,;-2.31,6.41,;-3.64,5.64,;-3.64,4.1,;-4.97,3.33,;-6.31,4.1,;-7.64,3.33,;-8.89,4.29,;-9.05,5.82,;-10.46,6.45,;-11.7,5.54,;-11.54,4.01,;-10.13,3.38,;-9.66,1.86,;-10.57,.62,;-12.09,.87,;-13.07,-.32,;-12.53,-1.76,;-11.01,-2.01,;-10.03,-.82,;-8.51,-1.07,;-8.12,1.86,;-7.21,.61,;-2.31,3.32,;-.97,4.1,)|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM21393
Synonyms:
7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol | 8-Hydroxy-2-(di-n-propylamino)tetralin | 8-OH-DPAT | 8-OH-DPAT,(+) | 8-OH-DPAT,(-) | 8-hydroxy-N,N-dipropylaminotetralin | CHEMBL1788118 | CHEMBL505765 | CHEMBL56 | DPAT | US10562853, Compound 8-OH-DPAT | [3H]-8-OH-DPAT | cid_1220
Type:
radiolabeled ligand
Emp. Form.:
C16H25NO
Mol. Mass.:
247.3758
SMILES:
CCCN(CCC)C1CCc2cccc(O)c2C1
Structure:
Search PDB for entries with ligand similarity: