Target

Ligand

Substrate

Meas. Tech.

pfHDAC-1 Enzyme Assay

pH

7.5±n/a

Temperature

296.15±n/a K

Citation

 Patel, V; Mazitschek, R; Coleman, B; Nguyen, C; Urgaonkar, S; Cortese, J; Barker, RH; Greenberg, E; Tang, W; Bradner, JE; Schreiber, SL; Duraisingh, MT; Wirth, DF; Clardy, J Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem 52:2185-7 (2009) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method

Name:

Histone deacetylase

Synonyms:

Histone Deacetylase (pfHDAC-1)

Type:

Enzyme

Mol. Mass.:

51371.91

Organism:

Plasmodium falciparum (isolate 3D7)

Description:

Assays were performed using recombinant pfHDAC-1 expressed and purified from S2 insect cells.

Residue:

449

Sequence:

MSNRKKVAYFHDPDIGSYYYGAGHPMKPQRIRMTHSLIVSYNLYKYMEVYRPHKSDVNELTLFHDYEYIDFLSSISLENYREFTYQLKRFNVGEATDCPVFDGLFQFQQSCAGASIDGASKLNHHCADICVNWSGGLHHAKMSEASGFCYINDIVLGILELLKYHARVMYIDIDVHHGDGVEEAFYVTHRVMTVSFHKFGDYFPGTGDITDVGVNHGKYYSVNVPLNDGMTDDAFVDLFKVVIDKCVQTYRPGAIIIQCGADSLTGDRLGRFNLTIKGHARCVEHVRSYNIPLLVLGGGGYTIRNVSRCWAYETGVVLNKHHEMPDQISLNDYYDYYAPDFQLHLQPSNIPNYNSPEHLSRIKMKIAENLRHIEHAPGVQFSYVPPDFFNSDIDDESDKNQYELKDDSGGGRAPGTRAKEHSTTHHLRRKNYDDDFFDLSDRDQSIVPY

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM19130

Synonyms:

(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide | CHEMBL99 | TSA | Trichostatin A (TSA)

Type:

Small organic molecule

Emp. Form.:

C17H22N2O3

Mol. Mass.:

302.3682

SMILES:

CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1|

Structure:

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Similarity to this molecule at least:

Name:

pfHDAC-1 Substrate

Synonyms:

n/a

Type:

fluorogenic, acetylated peptide

Mol. Mass.:

1609.93

Organism:

n/a

Description:

n/a

Residue:

15

Sequence:

ACLEGLYLYSACAMC