Target

Ligand

Substrate

Meas. Tech.

pfHDAC-1 Enzyme Assay

pH

7.5±n/a

Temperature

296.15±n/a K

Citation

 Patel, V; Mazitschek, R; Coleman, B; Nguyen, C; Urgaonkar, S; Cortese, J; Barker, RH; Greenberg, E; Tang, W; Bradner, JE; Schreiber, SL; Duraisingh, MT; Wirth, DF; Clardy, J Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem 52:2185-7 (2009) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method

Name:

Histone deacetylase

Synonyms:

Histone Deacetylase (pfHDAC-1)

Type:

Enzyme

Mol. Mass.:

51371.91

Organism:

Plasmodium falciparum (isolate 3D7)

Description:

Assays were performed using recombinant pfHDAC-1 expressed and purified from S2 insect cells.

Residue:

449

Sequence:

MSNRKKVAYFHDPDIGSYYYGAGHPMKPQRIRMTHSLIVSYNLYKYMEVYRPHKSDVNELTLFHDYEYIDFLSSISLENYREFTYQLKRFNVGEATDCPVFDGLFQFQQSCAGASIDGASKLNHHCADICVNWSGGLHHAKMSEASGFCYINDIVLGILELLKYHARVMYIDIDVHHGDGVEEAFYVTHRVMTVSFHKFGDYFPGTGDITDVGVNHGKYYSVNVPLNDGMTDDAFVDLFKVVIDKCVQTYRPGAIIIQCGADSLTGDRLGRFNLTIKGHARCVEHVRSYNIPLLVLGGGGYTIRNVSRCWAYETGVVLNKHHEMPDQISLNDYYDYYAPDFQLHLQPSNIPNYNSPEHLSRIKMKIAENLRHIEHAPGVQFSYVPPDFFNSDIDDESDKNQYELKDDSGGGRAPGTRAKEHSTTHHLRRKNYDDDFFDLSDRDQSIVPY

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM29600

Synonyms:

benzylidenehydrazine derivative, 17

Type:

Small organic molecule

Emp. Form.:

C15H20BrN3O5

Mol. Mass.:

402.24

SMILES:

COc1cc(C=NNC(=O)CCCCCC(=O)NO)c(Br)cc1O |w:5.4|

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

pfHDAC-1 Substrate

Synonyms:

n/a

Type:

fluorogenic, acetylated peptide

Mol. Mass.:

1609.93

Organism:

n/a

Description:

n/a

Residue:

15

Sequence:

ACLEGLYLYSACAMC