Target

Ligand

Substrate

Meas. Tech.

Enzyme Inhibition Measurements

pH

3.1±n/a

Temperature

295.15±n/a K

Citation

 Machauer, R; Veenstra, S; Rondeau, JM; Tintelnot-Blomley, M; Betschart, C; Neumann, U; Paganetti, P Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors. Bioorg Med Chem Lett 19:1361-5 (2009) [PubMed]  Article Copy BDB DOI

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Name:

Cathepsin D

Synonyms:

CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor

Type:

Enzyme

Mol. Mass.:

44551.72

Organism:

Homo sapiens (Human)

Description:

Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.

Residue:

412

Sequence:

MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL

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Name:

BDBM29744

Synonyms:

hydroxyethylene tripeptide inhibitor, 1

Type:

Small organic molecule

Emp. Form.:

C25H49N3O4S

Mol. Mass.:

487.739

SMILES:

CCCCNC(=O)[C@H](C)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)CCC(C)C |r|

Structure:

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Similarity to this molecule at least:

Name:

Cathepsin D Peptide Substrate

Synonyms:

n/a

Type:

Peptide

Mol. Mass.:

2375.29

Organism:

n/a

Description:

Peptide substrates were obtained from Bachem (Bubendorf, Switzerland).

Residue:

20

Sequence:

MCAGKPILFFRLKDNPDRNH