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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM395163
Substrate
n/a
Meas. Tech.
Determination of Allosteric Potency EC50 Values for Muscarinic M1 Receptor
EC50
699±n/a nM
Citation
 Nirogi, R; Mohammed, AR; Shinde, AK; Gagginapally, SR; Jasti, V Muscarinic M1 receptor positive allosteric modulators US Patent  US10308620 Publication Date 6/4/2019 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM395163
Synonyms:
US10308620, Example 9
Type:
Small organic molecule
Emp. Form.:
C23H26N2O4
Mol. Mass.:
394.4635
SMILES:
COc1cccc(CN2C=C(Oc3ccccc23)C(=O)N[C@H]2CCCC[C@@H]2O)c1 |r,c:9|
Structure:
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