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Target
Mitotic checkpoint serine/threonine-protein kinase BUB1
Ligand
BDBM395275
Substrate
n/a
Meas. Tech.
Bub1 Kinase Assay
IC50
5.00±n/a nM
Citation
 Graham, K; Klar, U; Briem, H; Siemeister, G; Mönning, U 1H-pyrrol-3-amines US Patent  US10308629 Publication Date 6/4/2019 
Target
Name:
Mitotic checkpoint serine/threonine-protein kinase BUB1
Synonyms:
BUB1 | BUB1A | BUB1L | BUB1_HUMAN | hBUB1
Type:
PROTEIN
Mol. Mass.:
122372.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1510603
Residue:
1085
Sequence:
MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKKKYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASAVLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGNNMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKEKLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKLHQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPPVVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSGAEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTLPDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGLPQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDFTSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEKSPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQAEWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLECKRSRK
  
Inhibitor
Name:
BDBM395275
Synonyms:
N-4-[[(7R) or (7S)]-7-Methyl-4-oxo-3-(phenylamino)-1,4,5,6,7,8-hexahydrocyclohepta[b]pyrrol-2-yl]pyridin-2-ylacetamide | US10308629, Example 39
Type:
Small organic molecule
Emp. Form.:
C23H24N4O2
Mol. Mass.:
388.4623
SMILES:
C[C@@H]1CCC(=O)c2c(C1)[nH]c(c2Nc1ccccc1)-c1ccnc(NC(C)=O)c1 |r|
Structure:
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