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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM349647
Substrate
n/a
Meas. Tech.
BIOLOGICAL ASSAY
IC50
1880±n/a nM
Citation
 Teall, M 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors US Patent  US10308635 Publication Date 6/4/2019 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM349647
Synonyms:
4-((3-Chloro-4-fluorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl) piperidine | US10208016, Compound of Example 17 | US10335402, Example 17
Type:
Small organic molecule
Emp. Form.:
C17H18ClF2N3O2S
Mol. Mass.:
401.859
SMILES:
Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)=C(F)c1ccc(F)c(Cl)c1 |(-5.11,1.2,;-5.88,-.13,;-7.34,-.61,;-7.34,-2.15,;-5.88,-2.62,;-5.11,-3.96,;-4.98,-1.38,;-3.44,-1.38,;-3.44,.16,;-3.44,-2.92,;-1.9,-1.38,;-1.13,-.04,;.41,-.04,;1.18,-1.38,;.41,-2.71,;-1.13,-2.71,;2.72,-1.38,;3.49,-2.71,;3.49,-.04,;2.72,1.29,;3.49,2.62,;5.03,2.62,;5.8,3.96,;5.8,1.29,;7.34,1.29,;5.03,-.04,)|
Structure:
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