Target
Nociceptin receptor
Ligand
BDBM30007
Substrate
BDBM29961
Meas. Tech.
In Vitro Binding Assay (IC50) and In Vitro Agonism/Antagonism Measurements (EC50/IC50)
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
16±n/a nM
EC50
46±n/a nM
Citation
 Kobayashi, KKato, TYamamoto, IShimizu, AMizutani, SAsai, MKawamoto, HIto, SYoshizumi, THirayama, MOzaki, SOhta, HOkamoto, O Optimization of benzimidazole series as opioid receptor-like 1 (ORL1) antagonists: SAR study directed toward improvement of selectivity over hERG activity. Bioorg Med Chem Lett 19:3100-3 (2009) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM30007
Synonyms:
Racemate | benzimidazole analogue, 7f
Type:
Small organic molecule
Emp. Form.:
C21H30ClN5O2S
Mol. Mass.:
452.013
SMILES:
CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](C3)NC(=O)OC)nc2cc1Cl |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM29961
Synonyms:
[125I]Tyr14-NC/OFQ | [125I]Tyr14-Nociceptin
Type:
radiolabeled substrate
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: