Target
Orexin receptor type 2
Ligand
BDBM395668
Substrate
n/a
Meas. Tech.
FLIPR assay
IC50
22.0±n/a nM
Citation
 Liverton, NKuduk, SDLuo, YMeng, NYu, T Piperidine oxadiazole and thiadiazole orexin receptor antagonists US Patent  US10308645 Publication Date 6/4/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM395668
Synonyms:
(1S)-2,2,2-trifluoro-1-{3-[(3R,6R)- 6-methyl-1-{[2-(2H-1,2,3-triazol-2- yl)phenyl]carbonyl}piperidin-3-yl]- 1,2,4-oxadiazol-5-yl}ethanol | US10308645, Example 7
Type:
Small organic molecule
Emp. Form.:
C19H19F3N6O3
Mol. Mass.:
436.3878
SMILES:
C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1noc(n1)[C@H](O)C(F)(F)F |r|
Structure:
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