Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM395683
Substrate
n/a
Meas. Tech.
FLIPR assay
IC50
10000±n/a nM
Citation
 Liverton, N; Kuduk, SD; Luo, Y; Meng, N; Yu, T Piperidine oxadiazole and thiadiazole orexin receptor antagonists US Patent  US10308645 Publication Date 6/4/2019 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM395683
Synonyms:
2-(3-{(3R,6R)-6-methyl-1-[(2- pyrimidin-2-ylthiophen-3- yl)carbonyl]piperidin-3-yl}- 1,2,4-oxadiazol-5-yl)propan-2-ol | US10308645, Example 22
Type:
Small organic molecule
Emp. Form.:
C20H23N5O3S
Mol. Mass.:
413.493
SMILES:
C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)c1noc(n1)C(C)(C)O |r|
Structure:
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