Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM395699
Substrate
n/a
Meas. Tech.
FLIPR assay
IC50
124±n/a nM
Citation
 Liverton, N; Kuduk, SD; Luo, Y; Meng, N; Yu, T Piperidine oxadiazole and thiadiazole orexin receptor antagonists US Patent  US10308645 Publication Date 6/4/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM395699
Synonyms:
2-{3-[(3R,6R)-6-methyl-1-{[2- (2,2,2-trifluoroethoxy)pyridin-3- yl]carbonyl}piperidin-3-yl]-1,2,4- thiadiazol-5-yl}propan-2-ol | US10308645, Example 38
Type:
Small organic molecule
Emp. Form.:
C20H24F3N3O3S
Mol. Mass.:
443.483
SMILES:
C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OCC(F)(F)F)c1nsc(n1)C(C)(C)O |r|
Structure:
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