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Target
Tumor necrosis factor
Ligand
BDBM395744
Substrate
n/a
Meas. Tech.
TNF induced HEK-Blue assay
IC50
5500±n/a nM
Citation
 Wrobleski, ST; Brown, GD; Lin, S; Duan, J; Lu, Z; Dhar, MT; Xiao, H; Tebben, AJ Tricyclic heterocyclic compounds useful as inhibitors of TNF US Patent  US10308652 Publication Date 6/4/2019 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM395744
Synonyms:
US10308652, Example 25
Type:
Small organic molecule
Emp. Form.:
C25H25FN4O3
Mol. Mass.:
448.4894
SMILES:
COc1cc(F)ccc1[C@@H]1NC[C@H](O)c2nc3ccc(nn3c12)-c1ccc(cc1)C(C)(C)O |r|
Structure:
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